A plane lands at John F. Kennedy International Airport with the lights off and doors sealed. Epidemiologist Dr. Ephraim Goodweather (Corey Stoll) and his team are sent to investigate. On board they find 206 corpses and four survivors. The situation deteriorates when all the bodies disappear from the morgue. Goodweather and a small group of helpers find themselves battling to protect not only their own loved ones, but the entire city, from an ancient threat to humanity.